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A few years ago, Dr Mercola stated that constant use of progesterone can cause ‘dermal fatigue’ – Dermal fatigue basically is a condition when the body’s adipose tissues undergo a process of saturation up till a point when further absorption is reduced.
He said: “Progesterone is highly a fat soluble hormone. After many applications, the fat tissue becomes saturated with the hormone and it does not provide any beneficial effects. After reaching the saturation point, progesterone may hamper the adrenal hormone, cortisol and testosterone.”
However, This Claim Is Not Substantiated
If it was so, overweight people who have been using progesterone for a long period, would be saturated with progesterone and could go a long way without applying the cream, considering the amount of progesterone stored in their body!
But this is not the case, because the estrogen dominance symptoms would return quite quickly after stopping the use of progesterone. Progesterone levels begin dropping in the blood after about 13 hours, necessitating using it at least twice a day.
Progesterone Doesn’t Just ‘Get Stuck’ In Your Fat Tissues
Both Progesterone and Vitamin D are made from cholesterol, both these molecules are very similar. Not only is Vitamin D fat soluble but it can also be converted into a steroid. Moreover, just like progesterone, Vitamin D can also be transported throughout the body from the skin.
Yes, it does enter the fat cells, as it’s not water soluble, but the fat contains capillaries and they have red blood cells in them. These red blood cells are responsible for picking up and distributing the progesterone to the other tissues present in the body.
Check this article in the ‘Menopause Journal’ – It says “However, one explanation is that after absorption through the skin, the lipophilic ingredients of creams, including progesterone, may have a preference for saturating the fatty layer below the dermis. Because there appears to be rapid uptake and release of steroids by red blood cells passing through capillaries, these cells may play an important role in transporting progesterone to salivary glands and other tissues.”, in other words saturated or not it still gets around the body.
But to remove it from your system, it does not require as much as 2 years either. Levels begin dropping after about 13 hours, necessitating using 100mgr to 200mgr of progesterone at least twice a day to reverse your symptoms.
Find out if you have Dermal fatigue
One way of finding out if you have dermal fatigue, is to drastically drop your progesterone intake for a few days, before increasing it again
If you experience oestrogen symptoms during that gap, you can be reassured that her receptors were working fine and that you do not have ‘Dermal fatigue’.
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