progesterone and vitamin D3

Lack of Vitamin D3 Reduces the Benefits of Progesterone

Progesterone is a sterol known to be the oldest hormone existing for over 500 years.Vitamin D3(cholecalciferol) is another sterol also known to be existing for hundreds of years and can even be as old as progesterone. It has been now proven that vitamin D3 deficiency hinders the benefits of progesterone. Everyone on progesterone therapy should test their VitD3 levels.

Most doctors say that the adequate level of blood levels are 30ng/ml (75nmol/L), however, the accepted recommendation should be 70-100ng/ml (175-250nmol/L). In addition, it’s also highly suggested that the minimum daily dosage of Vitamin D must be at least 5000IU, while the most recent research study say that it must be at 10,000IU per day. Find Study here

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How does VitD Work?

Vitamin D3 can be naturally converted to a steroid hormone by our own body through series of internal processes. The liver converts it first to 25-OHD3 (calcidiol), and then by the kidneys in conjunction with other tissues to 1,25-OH2D3 (calcitriol).

In 1929, Progesterone was found and identified.

In 1937, Vitamin D was finally segregated.

Another sterol popularly known as cholesterol is responsible for the production of progesterone and vitamin D3 inside the body. Progesterone is processed through the brain, glial cells, adrenals, ovaries and testes. On the other hand, Vitamin D3 is formed by UVB ray of the sunlight as it penetrates the cholesterol inside the skin.

Corticosteroids and mineralocorticoids are formed when progesterone is further transformed inside the body. Oestrogens, oestrone, oestradiol and oestriol are also formed if progesterone is processed together with androstenedione and testosterone.

In late 2009, a research study concerning progesterone and vitamin D3 has been published saying that Vitamin D3 deficiency hinders the progesterone to reach its optimum potential in providing health benefits.

Benefits of Progesterone and vitamin D3

Progesterone and vitamin D3 have a lot in common, may it be in their forms
or the benefits they could give to our well-being. Both of them do :

  • Influence positive the response of anti-inflammatory Th2
  • Inhibit the Th1 inflammatory response
  • Inflammatory cytokines liketnf-a, IL2, and IL6 are suppressed
  • Anti-swelling cytokines such as IL-10 are increased
  • Mast cell productions and discharges are prevented
  • Preventing theinfluence of oestrogen to grow in dendritic spine density
  • The manner of brain-derived neurotrophic factor (BDNF) are increased
  • Neurologic functioning are definitely affected
  • Intensify myelin repair and induce neurodegeneration and
  • Motorneuron disease are affected in a positive way
  • Harmful brain injury damage is reduced
  • Hypertension occurence becomes lesser
  • Regulate bone metabolism
  • Prevent lipid peroxidation
  • Are essential for pregnancy
  • Positively affect the skin and hair
  • Glutathione concentrations, which is the cells master antioxidant, are increased
  • The levels of a powerful antioxidant,superoxide dismutase, are increased
  • Inhibit mitosis, causing cell differentiation and apoptosis
  • Expression of glucocorticoids are regulated
  • Fibroblast and collagen synthesis growths are regulated

It is important to maintain an adequate level of progesterone and vitamin D.
A lower level of these two are both found in the following diseases and disorders, thus, increasing the risk for:

  • Asthma And Respiratory Problems
  • Depression
  • Early Ageing
  • Cancer
  • Epilepsy
  • Heart Disease
  • Migraines/Headaches
  • Polycystic Ovaries
  • Miscarriage
  • Fibroids
  • Peripheral Neuropathy
  • Myopathy
  • Sjogren’s Syndrome, Arthritis, Ms, Lupus, And Many More
  • Sad (Seasonal Affective Disorder)
  • Alzheimer’s disease (a neuroactive metabolite of progesterone, low allopregnanolone, is a favorable biomarker in dementia)

Progesterone and vitamin D both have a beneficial effect to the cell growth and differentiation, as well as, to the characteristics of the gene. They also both have anti-oxidative and autoimmune anti-inflammatory mechanisms. Nervous system can also function well with these two hormones because they stabilize oxidative hyperactivity, fuel neurotrophic factors, and maintain autoimmune responses.

For additional references or information regarding Vitamin D like its adequate level and test kits among others, you may want to visit the links below:

Vitamin D Council
Birmingham Hospital
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