‌  When & how much Natpro to use

The cream can be used at any time of the day and, if preferred, on more than one occasion, but no less than twice a day, as progesterone levels drop after about 13 hours. It can be applied to any part of the body and does not have to be used only on thin-skinned areas as is sometimes recommended. The skin comprises 95% keratinocytes, which have a plentiful supply of progesterone receptors, even the hair follicles absorb it well.

Please note the amount suggested is a guide only as each individual is different.  It’s only by trial and error that the correct amount is found. Another point to remember is that stress drops progesterone levels sharply so apply more to prevent the return of symptoms.

Progesterone should always be used dependant on symptoms and not on ‘dose’. If symptoms are severe more will be needed, if mild then less.

Generally, between 100-200mg/day of progesterone (that is 3ml to 6ml of cream) is needed.
Each pump action provides 1.5 mls per squirt.
1.5mls is equal to 50mgr of active progesterone.

Supplemental progesterone can initially make a person more sensitive to the oestrogen in their body. Because of this, oestrogen dominance may occur which can be very disconcerting. The following is a short list of what can be encountered …..

  • breast tenderness
  • bloating/weight gain from water retention
  • spotting or a temporary reappearance of your periods
  • headaches/ migraines/ dizziness
  • hypoglycaemia
  • aches and pains or bruising
  • depression
  • tiredness/chronic fatigue
  • hot flushes
  • mood swings
  • anger
  • skin problems
  • nausea

Before using Natpro, it is important to understand ‘estrogen dominance symptoms’, click the link below:



If a cycle is present apply the cream twice daily from ovulation for the next 14 days, bleeding should occur within a day or two.  The luteal phase is always 12-14 days in all women, any less and it’s known as a ‘defective luteal phase’ Cycles vary from 21 days to 36 days. For instance, in a 21-day cycle the cream should be used from day 8 for 14 days, if a 28-day cycle from day 15 for 14 days, and if a 36 day cycle from day 22 for 14 days.

Peri or post Menopausal, Hysterectomy, Oophorectomy, Pre-pubertal, Pubertal

If there is no cycle, or an erratic one too difficult to follow, apply the cream twice daily. There is no need for a break as some suggest, although some women prefer to have one.  Either is fine.

Severe symptoms

Hot flushes  Use at least 400mg/day for 4-5 days, this generally stops them. It’s best to apply the cream hourly.

Heavy, continual bleeding  400-600mg/day from 1 to 3 months, ignoring the cycle.  When the bleeding has stopped, slowly reduce the cream until bleeding occurs again, then discontinue the cream for 14 days. Then start again from day 15 for 14 days. Over the coming months, the natural cycle length will assert itself. It’s best to apply the cream hourly.

A multitude of bad symptoms Use a minimum of 200mg/day following the cycle, more might be needed. If symptoms return during the break, then continue applying the cream twice daily or more frequently until they resolve.  Once they have then begin following the cycle again.


Use from 10 to 100mg/day of progesterone (that is 0.3ml to 3 ml of cream).  It’s best applied twice a day.

Natpro cream dispenser content

• Each dispenser contains 100 grams (3.5 oz) of cream
• See here for recommended usage levels
• Natpro cream has a concentration of 3.33% progesterone or 33.33 milligrams per gram
• Each dispenser contains :
de-ionised water
caprylic/capric triglyceride
cetearyl olivate/sorbitan olivate
progesterone Ph. Eur. USP. JP.
Aspen bark extract
dehydroxanthan gum
vitamin E
• Natpro has an unopened shelf life of 18 months

‌‌‌   Natpro Pump cream content

Natpro contains only vegetable substances. No animal has suffered or will ever suffer because of its production or use. Natpro progesterone cream does not contain any toxic substances – such as growth hormones – found in today’s animal products. You are protected.

Here’s a note on recent changes made to Natpro’s formula…
The formulation for Natpro progesterone cream has remained almost unchanged since it was originally developed in the years 1996/7. Well, that’s now changed.


The pursuit of an organic natural progesterone cream that is free of both “parabens” and “PEG” has long remained my dream and it’s now been realized. It’s taken a long time coming and I’ll make no secret of the fact that the path has led down many blind allies and hit many obstacles. The real difficulty has been in getting a “paraben-free” preservative system that doesn’t simply substitute another “unnatural” ingredient.

What’s wrong with parabens?

There are relatively rare documented instances where parabens have been found to cause skin irritation, contact dermatitis, or allergic skin reactions. They are considered to be of low irritation potential compared with many other preservatives. Although there is no evidence that any cosmetics containing parabens pose a health risk they can, however, cause reactions in individuals with paraben allergies. Only a tiny percentage of the general population is allergic to parabens. Some studies have led to concerns over their continued use, and there is currently a shift away from them. This is despite the rejection of the breast cancer tissue study by the majority of the scientific community, and the extremely weak estrogenic effect found for butylparaben (no effect was seen with methyl or propyl parabens previously used in Natpro).

Despite this, my attitude has been… “why take any risk when it can be avoided?”

Most organic preservatives simply can’t stand up to the rigorous “challenge testing” required to meet the necessarily high standards to ensure aqueous creams avoid becoming breeding grounds for toxic molds and bacteria. There are many organic preservatives out there that are touted as doing the job. The truth is they simply don’t do a good enough job without “support” from conventional preservatives such as parabens. Take the much-publicized “grapefruit seed extract”… it simply can’t work alone.

Natpro’s new system works.

It has undergone rigorous challenge testing. But that’s not all that’s different. We’ve also changed (again after much painstaking research) the emulsifying agents to a completely “PEG free” combination.

What’s “PEG” mean?

Well, its shorthand for ‘polyethylene glycol’. Its found in many formulas and has been causing some concern in recent times as a potential health hazard. Although this is far from proven I decided to act now rather than later so we developed an alternative system that is entirely “PEG free”.

The new Natpro progesterone cream formula is about as natural as you can get. I’m also particularly pleased because its “emolience” or “feel quality” is, if anything, an improvement on the old formula. But perhaps most important of all… …its functional ability to ensure the efficient transdermal delivery of the progesterone itself is second to none. This has been established through rigorous, repeated saliva testing.

Let’s look at the contents in more detail :

• The progesterone in Natpro is identical to the progesterone your body makes. ‘Progesterone Ph. Eur. USP JP’ is derived principally from stigmasterol, a steroidal sapogenin. Phytosterols are chemically similar to cholesterol which is found in animals. Cholesterol is the starting point for the hormones made naturally in animals, including humans. Plants such as the soy bean, Dioscorea species of yams, fenugreek, sisal, calabar bean, some lilies, yucca, some solanum species, maize, and many more contain phytosterols, some of which are stigmasterol, diosgenin, sitosterol, campesterol, hecogenin, smilagenin, sarsasapogenin, solasodine. As these sterols have a similar molecular structure to progesterone they are used as starting points for the synthesis of progesterone. In the southern United States the sweet potato (Ipomoea batatas) is called a yam, as are some edible members of the aroids. These plants do not contain any sapogenins.

Don’t confuse Natpro progesterone cream with a bean or yam “extract”. Such extracts do not contain progesterone.

caprylic/capric triglyceride – is a ‘medium chain’ triglyceride of fractionated vegetable fatty acids extracted from coconut oil. It is colourless, neutral in odour and taste and has a very low viscosity. It has very good resistance to oxidation. It is an ideal ‘carrier’ for progesterone, as it penetrates the skin readily and is easily absorbed. It does not leave a greasy film and helps to retain moisture. Very importantly… it’s not a mineral oil and is unrefined.
Lets examine these points more closely:
o Mineral oils, being petro-chemicals, are potentially harmful because they are “endochrine disruptors”. They rob your body of the oil soluble vitamins A, D, E & K , and so deprive you of vital nutrients. Never use any product on your skin that contains mineral oils.
o Heating or refining any vegetable oil causes damage. The good “cis” fatty acids that are found in vegetable oils are turned into bad “trans” fatty acids and the result is highly carcinogenic. Don’t use refined oils.

Vitamin E (dl-alpha tocopherol) – All emulsions made with vegetable oils have the potential to go rancid. For this reason dl-alpha tocopherol is used as it’s an ‘in vitro’ antioxidant. Standard preparations contain only 0.1%, however, Natpro progesterone cream contains a further 0.2%.

The new two part emulsifier system… cetearyl olivate/sorbitan olivate – a unique natural PEG-free organic emulsifier from Olive oil. It reduces skin water loss, has a high moisturizing effect, is hypoallergenic and biomimics the skin.

The new natural preservative system… Aspen bark extract – is a natural organic preservative and as such is a unique discovery as it is an effective natural replacement for commonly used harmful chemical preservatives such as the ‘parabens’. It also improves the emollience (the ‘feel-good’ factor) of the cream.

dehydroxanthan gum – is an Eco Certified, non GMO film former, fixative and emulsion stabilizer. It provides unprecedented hold under highly humid conditions without being tacky or flaking.

de-ionized water – this is a pure pharmaceutical grade standard.

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