Posts Tagged: tag 1

Absolutely, natural progesterone can suppress endometriosis!
Oestrogen will stimulate endometriosis whereas progesterone will prevent it.

In the mechanism of cell multiplication, it is oestrogen which is responsible to trigger the BCL 2 gene which causes the cells to multiply uncontrollably – On the other hand progesterone switches OFF the BCL 2 gene and switches ON the P53 gene which sends messages to the cell to mature and die.

If this message is not switched off by Progesterone, then the cells which lines the uterus continue to multiply and go wild …. causing Endometriosis.

 As oestrogen is the problem, AVOID all form of oestrogen!

 Endometriosis is caused by the imbalance between too much oestrogen and a deficiency of progesterone.  This unopposed oestrogen results in many ‘symptoms of oestrogen dominance’ including endometriosis.

Using natural progesterone cream for endometriosis over a few months can help reverse this condition

BEWARE OF GETTING OESTROGEN DOMINANT!

In fact, we live in a “Sea of oestrogens

  • We are surrounded by Xeno-oestrogens in the environment (molecules that mimics the action of oestrogen). These are mostly found in petrochemicals such as insecticides, plastics, mineral oil-based creams, household products, car fumes and others.
  • The Pill or HRT also contains estrogen and synthetic progesterone which will cause oestrogen dominance.
  • When the ovaries don’t produce and release the egg it will cause oestrogen to rise. During an anovulatory cycle, the corpus luteum doesn’t produce ANY progesterone and oestrogen becomes the dominant hormone. Today, on average, this happens around the age of 34 years old!

Progesterone is the only antagonist to too much oestogen.

PROGESTINS FOUND IN HRT & THE  PILL WILL HINDER EFFECTIVENESS OF NATURAL PROGESTERONE

Synthetic Progestins such as Megestrol and Provera compete with the receptor binding sites normally reserved for Progesterone. Progesterone taken together with these synthetic hormones will not work. You are advised to withdraw from using synthetic Progestins as found in the pill or HRT gradually before starting to use Natural Progesterone for treatment of Endometriosis.

HOW MUCH PROGESTERONE FOR SUPPRESSING ENDOMETRIOSIS

  1. For normal use between 100-200mg/day of progesterone is sufficient but in severe cases 500mg/day will be needed, its best to go by symptoms, adjusting it higher or lower as the weeks go by.
  2. Rub the cream on any part of the body that has good circulation before bed time – beasts, neck, chest, legs, arms, thighs, soles of the feet, or back.
  3. If you have a lot of body fat, the progesterone will be soaked up by the body fat first before getting into your blood stream. You may then need a higher dose to deal with endometriosis.

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Many women are infertile due to multiple early miscarriages!
In my interview with Wray Whyte, she shows us that if early progesterone fails to rise, after ovulation, implantation doesn’t take place.

Many women could possibly be miscarrying after two weeks, but not even aware that they’re pregnant, because they bleed, but they could be bleeding an embryo that is fertilized. “ and she went on to explain how to prevent this issue by using progesterone.
Interesting to see what she said a few years ago is being backed recently, by team of researchers at the Yale School of Medicine and University of Illinois at Chicago, who stated: “Micronised plant-derived progesterone could give hope to women who suffer multiple miscarriages in the first four to five weeks of pregnancy.” (*ref:1)

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Can Infertility & Miscarriage be caused by a lack of Progesterone?
Transcript of the Interview

Vero: Let’s speak on the fertility issue because it’s something that…

Wray: Yes, that’s fine.

Vero: carries so much…emotion.

Wray: Yes.

Vero: and the woman can be so desperate and really trying anything to fall pregnant.

What are the causes of Infertility & Miscarriage?

Wray: It’s such a huge topic. And there are so many things that can cause infertility. One, of course, is nutrition, not having the right nutrients. I think, going back to vitamin D again, a lack of it can cause anovulation.  It can stop ovulation. And if you don’t ovulate, you won’t fall pregnant.  And if this happens, the women are put onto ovulation stimulation drugs, rather than trying natural things like vitamin D.

I find very intriguing because it’s something that you never hear about it, or you never read about it. Everybody is told, and everybody believes, that progesterone only rises at ovulation.  And this isn’t true.  There’s a pre-ovulatory rise up to 50 hours prior to ovulation.  And it’s coming from the brain.  And they now believe that this rise in progesterone from the brain (***ref:1) causes LH (Luteinizing Hormone) to rise, which then initiates ovulation.  And it’s not LH rising and causing ovulation, it needs the progesterone to rise, so in other words, progesterone is initiating ovulation itself.  But it’s directed from the brain because prior to this sort of discovery, they thought that progesterone was only produced by the corpus luteum, not by the brain.  Well there’s been huge research now and it is produced by the brain.

So this surge of progesterone prior to ovulation, causing LH to surge, causing ovulation…so progesterone keeps rising because after ovulation obviously it keeps rising. I think instead of giving ovulation induction drugs, which causes LH to rise, causing ovulation, try progesterone before ovulation, within that 50 hour time span.

And I would be so fascinating to find if using progesterone, just those few hours prior to ovulation would cause your LH to go up, which will then cause you to ovulate, rather than take the drugs.  They’ve never done a study on it. But it’s worth trying. And then…they’ve also found essential to egg implantation, is an early progesterone rise, after ovulation.  If it’s too low, implantation doesn’t take place.  So again, if you use progesterone within the 50 hours before ovulating, that would ensure you have that early progesterone rise after ovulation because you’re now full of progesterone.  And the egg implantation would be much more successful.

And then the other thing of course, is where the corpus luteum doesn’t make enough progesterone.  So then they’re given drugs like HCG to stimulate the corpus luteum to make more progesterone.  But it’s so interesting because another study has found that progesterone itself causes…or stimulates, its own, production.  There is no negative feedback system in that corpus luteum-progesterone, cycle.  It’s unlike any other system in the body, which always has that negative feedback. It doesn’t with progesterone, you know with the progesterone cycle.  So using progesterone prior to ovulation would give you that first initial rise which would help ovulation; it would also ensure that you have the high initial rise which is vital for implantation and then it would also continue to give you the progesterone if the corpus luteum is not making enough.  So your chances of success are greater.

And then, you’ll know two weeks later, if you you’ve conceived at ovulation, or roundabout, and, but if you’re not using enough progesterone, it doesn’t support that pregnancy.

So I think that many women could possibly be miscarrying after two weeks, but not even aware that they’re pregnant, because they bleed, but they could be bleeding an embryo that is fertilized.  And so, if you use progesterone for helping with pregnancy, it’s essential not to stop it if you are using it, [like, when you follow your cycle], because if you stop you’ll bleed.  So you would continue using the progesterone.

Continue using Progesterone if you don’t bleed!

If you’re not pregnant, you will bleed.  Even if it’s a few days later, you will, unless you’re using very, very high doses like 400mg a day. You will bleed.  And then you can stop using the cream.  But if you don’t bleed, then the chances are you are pregnant and therefore you must continue on with it.

The other thing that saddens me is that women are given progesterone, usually suppositories, if they’re, they’ve had, intrauterine insemination (IUI) or in vitro fertilization (IVF), and then they’re given it for maybe six weeks, or two months, at the most for three months and then they’re told to stop.
Now that’s going cold turkey off progesterone.  And one of the causes of miscarriages is a drop in progesterone.  So they must never go cold turkey off of it, they come off it very, very slowly.  That’s why I prefer the cream because you can do it slowly.  With suppositories, well I’ve had to tell the girls “well, cut the suppository into bits, and use the bits.” You know, how do you do slowly?  Same with injections.  You can’t slowly reduce on an injection. It’s sort of all or nothing.

Just as a recap, progesterone 50 hours before ovulation, or in that range, continue with it (progesterone), right through when you would be getting your period, i.e. two weeks later; and if you bleed, then you stop using the cream.  If you don’t, continue, then you’ll have a test and then, hopefully, you’re pregnant.

Vero: How much progesterone when we talk about infertility, what would be the recommended doses?

Wray: Well, I always stick to 100-200mg daily and always use the progesterone before falling pregnant.  So many women fall pregnant but because the doctor might be worried about miscarriages, they’ll be given progesterone at, maybe, the four week interval: they’re now four weeks pregnant. They get estrogen dominance, all the symptoms.  And they must use it before they fall pregnant.  And overcome all that, learn how to use it, what it feels like etc., before falling pregnant.

(*ref:1)
https://www.figo.org/news/progesterone-could-be-key-preventing-recurrent-miscarriage-0015458

(**ref:2)
https://www.ncbi.nlm.nih.gov/pubmed/1730816
http://womeninbalance.org/resources-research/progesterone-and-the-nervous-systembrain/

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A few years ago, Dr Mercola stated that constant use of progesterone can cause ‘dermal fatigue’ – Dermal fatigue basically is a condition when the body’s adipose tissues undergo a process of saturation up till a point when further absorption is reduced.

He said: “Progesterone is highly a fat soluble hormone. After many applications, the fat tissue becomes saturated with the hormone and it does not provide any beneficial effects. After reaching the saturation point, progesterone may hamper the adrenal hormone, cortisol and testosterone.”

However, This Claim Is Not Substantiated

If it was so, overweight people who have been using progesterone for a long period, would be saturated with progesterone and could go a long way without applying the cream, considering the amount of progesterone stored in their body!
But this is not the case, because the estrogen dominance symptoms would return quite quickly after stopping the use of progesterone. Progesterone levels begin dropping in the blood after about 13 hours, necessitating using it at least twice a day.

Progesterone Doesn’t Just ‘Get Stuck’ In Your Fat Tissues

Both Progesterone and Vitamin D are made from cholesterol, both these molecules are very similar. Not only is Vitamin D fat soluble but it can also be converted into a steroid. Moreover, just like progesterone, Vitamin D can also be transported throughout the body from the skin.

Yes, it does enter the fat cells, as it’s not water soluble, but the fat contains capillaries and they have red blood cells in them. These red blood cells are responsible for picking up and distributing the progesterone to the other tissues present in the body.

Check this article in the ‘Menopause Journal’ –  It says “However, one explanation is that after absorption through the skin, the lipophilic ingredients of creams, including progesterone, may have a preference for saturating the fatty layer below the dermis. Because there appears to be rapid uptake and release of steroids by red blood cells passing through capillaries, these cells may play an important role in transporting progesterone to salivary glands and other tissues.”, in other words saturated or not it still gets around the body.

But to remove it from your system, it does not require as much as 2 years either. Levels begin dropping after about 13 hours, necessitating using 100mgr to 200mgr of progesterone at least twice a day to reverse your symptoms.

Find out if you have Dermal fatigue

One way of finding out if you have dermal fatigue, is to drastically drop your progesterone intake for a few days, before increasing it again
If you experience oestrogen symptoms during that gap, you can be reassured that her receptors were working fine and that you do not have ‘Dermal fatigue’.

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Straight Talks with Wray Whyte…

So often, we get confused about the right amount of Progesterone Cream necessary to help us get rid of our estrogen symptoms. In my interview with Wray Whyte, she clears many common misunderstandings and gives us the essential guidelines for the cream to be effective.  

Want to learn more about Progestone Therapy? => click here and Grab your Free Videos Series with the Expert

Transcript of the Interview

Wray Whyte: I think in almost every one of the queries I get, and I get quite a few, they all ask how much cream to use, how much progesterone to use and I spend my life on a calculator because a lot of the people who write in use another cream with varying strengths.

So I have to work out for them how much and of course they’re always alarmed because most of the time, they have to use half the container to get the amount I suggest. But as far as dose is concerned, it really depends on symptoms. It doesn’t depend on weight, age, height at all and it depends a bit on sex because a man doesn’t need as much. But the problem is how much estrogen does a woman have in her body.

The more estrogen, the more progesterone is needed and what I’m finding, if women get the courage and listen to what I say and use a lot which is sometimes 10 times what they have been using. They are given 20 to 40 milligrams a day to use and I would say to use 100 to 200 or more… and they’re alarmed in this but there are some who listen and they are the ones that respond dramatically.

I have found and it was interesting that one girl had a doctor put her on 400 milligrams immediately. She had no estrogen-dominance symptoms at all, none, and I found women who do that, go really high (in progesterone dosage), don’t often get the symptoms. But I’ve got women using 1000 milligrams a day, half a tube. It’s a huge amount because their symptoms are just so bad and so it really depends only on symptoms which again are a reflection of how much estrogen you have in you. Not size, not weight, not height…. But symptoms, and to go high (to use a high dosage of progesterone)

Vero Laos: Yes. Actually, what you are saying is so interesting because we presume that just taking that little scoop everyday would be sufficient and as you say, it’s how much estrogen and how much estrogen-dominance we have is directly related to the amount of symptoms that we have. So then one would start on a high dose. What would be the regime that you would advice let’s say for the first three months?

Wray Whyte: If somebody is pre-menopausal i.e. they got a regular cycle but are having horrific symptoms, I tell them to ignore the cycle. So in other words, they would use the cream everyday and through their period as well and I say do this for two to three months. Sometimes they require longer, sometimes shorter but it doesn’t harm to use it through the cycle and what this means is that it gives progesterone a chance to become dominant. If you take a break, estrogen can rise so you’re back to square one every time you start the progesterone.

Going continuously on the cream, it suppresses estrogen continuously so it cannot rise and generally, at the end of the three months, the progesterone is now dominant and then once they sort of feel stable, they can start experimenting. They stop the cream and then see what happens. If the symptoms come back, they obviously haven’t gone on long enough but if the symptoms don’t come back, then they can continue not using the cream for the length of the follicular phase that they normally have.

Now this is another confusing thing because everyone is told to use the cream for 14 days and have a break for 14 days. Twenty-eight days is only the average length of our cycles. They range from 21 days to 35 days. If you add those two together, divide by two, you get to 28 and so the pill manufacturers put their pill in a 28-day package.

Everyone now thinks every woman has a 28-day cycle and it’s simply not true. So a woman with a 35-day cycle, she would only start using progesterone on day 21 and use it for the next 14 days. So she doesn’t use it (the cream) for three weeks but somebody with a very short cycle, 21 days,… she would start using it on day seven and use it for the next 14 days.

So you have to know… but there are some women who have erratic cycles some don’t, in which case you use the average.

Vero Laos: You would advise women with very bad estrogen dominance symptoms, not to respect the 14/14 days over the three months but just to use the cream the whole month and every day.

Wray Whyte: Things (the cycle will) sort themselves out. They don’t feel as bad because to my mind, it’s far better to use the cream daily and get rid of the symptoms. I feel it’s a small price to pay because sometimes, the cycle can get upset. So instead of a regular cycle, using it daily can make the cycle shorter or longer but that’s not the problem. It will sort itself out again once you start following the cycle.

So it’s important to realize for the recapping: size, weight, height do not play any part in it. The symptoms play the part. The worse the symptoms, the more progesterone is needed to overcome them and the longer normally you have to use it and I found using for two to three months daily, is sort of generally OK. Some women need longer.

Then if you feel stable, start following your cycle and the best is to start a 28-day and then your normal cycle will sort of flow from there and then things should start getting better but I found also estrogen dominance can come out of the blue. Some women can be coasting along for three months and they’re perfectly happy and then suddenly they get hit and I get this sort of panic letter. Sometimes there is no explanation for it. It’s usually stress.

Progesterone drops, estrogen rises. Symptoms come back. What causes this stress? It’s obviously the individual would know but that is something to be aware of. Estrogen can rise again and hit you suddenly without realizing it and there are so many factors now that cause estrogen to rise.

I’ve just finished answering somebody. Even milk which contains the bovine growth hormone causes IGF-1 to increase. This is insulin-like growth factor and that increases aromatase in the body. Aromatase converts more testosterone into estrogen …. so you get estrogen rising. We just don’t know what we’re doing with ourselves. At any one time, we could be eating a huge amount of phytoestrogens without realizing it and they’re in grains and legumes mainly. So, estrogen rises again. There are so many variables. It’s impossible to say but if it does happen, increase the cream again. Increase the progesterone.

Vero Laos: Excellent, Wray. That’s so interesting. So often we just follow the mainstream and we think we are OK but our health really matters and we have to be responsible. We have to know about our hormones. We have to know what causes such imbalance and how to preserve ourselves. We want to live long and we want to live healthy ……. and happy of course. I really appreciate your work and the way that you are really helping women all over. Thank you so much, Wray.


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I met with Wray Whyte in 2000 when I started using progesterone cream.

We became friends and later on I had the privilege of working alongside her to
help women make informed choices to take control of their health.

I interviewed Wray on several occasions on the benefits of progesterone therapy!

In March 2012, as we were heading to Greyton, in the beautiful Cape Province in South Africa, I did a series of interviews with her.

I’d like to share some footage of our travel through the Karoo together…with some fun moments.
As a Tribute to our beloved Wray who left us too soon!

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Wray Whyte was a champion in helping thousands of women balance their hormone naturally and regain their health. She was bright, generous and worked relentlessly as an advocate of natural hormonal balance.

Her legacy will continue to help women make informed choices about their health.

She made that statement about estrogen dominance:

“As estrogen is rising all over the world because of the environmental toxins, most of us are Estrogen dominant! We also consumed a significant amount of grains and legume which are estrogenic.
The main symptoms of estrogen dominance are weight gain, mood swings, depression and much more. Estrogen has valuable attributes which we need obviously – but some we don’t.
It is called an ‘inflammatory and excitatory hormone’ . It is a mitogen, in other words, it causes cells to proliferate whereas progesterone inhibits mitosis, so it stops the cells proliferating. Progesterone is also an anti-inflammatory and anti-oxidant – that is why I advocate using it to counter any possible estrogen dominance.”

You can access all of Wray’s interviews by requesting the free video series – interviews with the Expert

What most people are getting wrong on Estrogen Dominance => Grab your Free Videos Series with the Expert

Straight Talks with Wray Whyte…

So often, we get confused about the right amount of Progesterone Cream necessary to help us get rid of our estrogen symptoms. In my interview with Wray Whyte, she clears many common misunderstandings and gives us the essential guidelines for the cream to be effective.  

Want to learn more about Progestone Therapy? => click here and Grab your Free Videos Series with the Expert

Transcript of the Interview

Wray Whyte: I think in almost every one of the queries I get, and I get quite a few, they all ask how much cream to use, how much progesterone to use and I spend my life on a calculator because a lot of the people who write in use another cream with varying strengths.

So I have to work out for them how much and of course they’re always alarmed because most of the time, they have to use half the container to get the amount I suggest. But as far as dose is concerned, it really depends on symptoms. It doesn’t depend on weight, age, height at all and it depends a bit on sex because a man doesn’t need as much. But the problem is how much estrogen does a woman have in her body.

The more estrogen, the more progesterone is needed and what I’m finding, if women get the courage and listen to what I say and use a lot which is sometimes 10 times what they have been using. They are given 20 to 40 milligrams a day to use and I would say to use 100 to 200 or more… and they’re alarmed in this but there are some who listen and they are the ones that respond dramatically.

I have found and it was interesting that one girl had a doctor put her on 400 milligrams immediately. She had no estrogen-dominance symptoms at all, none, and I found women who do that, go really high (in progesterone dosage), don’t often get the symptoms. But I’ve got women using 1000 milligrams a day, half a tube. It’s a huge amount because their symptoms are just so bad and so it really depends only on symptoms which again are a reflection of how much estrogen you have in you. Not size, not weight, not height…. But symptoms, and to go high (to use a high dosage of progesterone)

Vero Laos: Yes. Actually, what you are saying is so interesting because we presume that just taking that little scoop everyday would be sufficient and as you say, it’s how much estrogen and how much estrogen-dominance we have is directly related to the amount of symptoms that we have. So then one would start on a high dose. What would be the regime that you would advice let’s say for the first three months?

Wray Whyte: If somebody is pre-menopausal i.e. they got a regular cycle but are having horrific symptoms, I tell them to ignore the cycle. So in other words, they would use the cream everyday and through their period as well and I say do this for two to three months. Sometimes they require longer, sometimes shorter but it doesn’t harm to use it through the cycle and what this means is that it gives progesterone a chance to become dominant. If you take a break, estrogen can rise so you’re back to square one every time you start the progesterone.

Going continuously on the cream, it suppresses estrogen continuously so it cannot rise and generally, at the end of the three months, the progesterone is now dominant and then once they sort of feel stable, they can start experimenting. They stop the cream and then see what happens. If the symptoms come back, they obviously haven’t gone on long enough but if the symptoms don’t come back, then they can continue not using the cream for the length of the follicular phase that they normally have.

Now this is another confusing thing because everyone is told to use the cream for 14 days and have a break for 14 days. Twenty-eight days is only the average length of our cycles. They range from 21 days to 35 days. If you add those two together, divide by two, you get to 28 and so the pill manufacturers put their pill in a 28-day package.

Everyone now thinks every woman has a 28-day cycle and it’s simply not true. So a woman with a 35-day cycle, she would only start using progesterone on day 21 and use it for the next 14 days. So she doesn’t use it (the cream) for three weeks but somebody with a very short cycle, 21 days,… she would start using it on day seven and use it for the next 14 days.

So you have to know… but there are some women who have erratic cycles some don’t, in which case you use the average.

Vero Laos: You would advise women with very bad estrogen dominance symptoms, not to respect the 14/14 days over the three months but just to use the cream the whole month and every day.

Wray Whyte: Things (the cycle will) sort themselves out. They don’t feel as bad because to my mind, it’s far better to use the cream daily and get rid of the symptoms. I feel it’s a small price to pay because sometimes, the cycle can get upset. So instead of a regular cycle, using it daily can make the cycle shorter or longer but that’s not the problem. It will sort itself out again once you start following the cycle.

So it’s important to realize for the recapping: size, weight, height do not play any part in it. The symptoms play the part. The worse the symptoms, the more progesterone is needed to overcome them and the longer normally you have to use it and I found using for two to three months daily, is sort of generally OK. Some women need longer.

Then if you feel stable, start following your cycle and the best is to start a 28-day and then your normal cycle will sort of flow from there and then things should start getting better but I found also estrogen dominance can come out of the blue. Some women can be coasting along for three months and they’re perfectly happy and then suddenly they get hit and I get this sort of panic letter. Sometimes there is no explanation for it. It’s usually stress.

Progesterone drops, estrogen rises. Symptoms come back. What causes this stress? It’s obviously the individual would know but that is something to be aware of. Estrogen can rise again and hit you suddenly without realizing it and there are so many factors now that cause estrogen to rise.

I’ve just finished answering somebody. Even milk which contains the bovine growth hormone causes IGF-1 to increase. This is insulin-like growth factor and that increases aromatase in the body. Aromatase converts more testosterone into estrogen …. so you get estrogen rising. We just don’t know what we’re doing with ourselves. At any one time, we could be eating a huge amount of phytoestrogens without realizing it and they’re in grains and legumes mainly. So, estrogen rises again. There are so many variables. It’s impossible to say but if it does happen, increase the cream again. Increase the progesterone.

Vero Laos: Excellent, Wray. That’s so interesting. So often we just follow the mainstream and we think we are OK but our health really matters and we have to be responsible. We have to know about our hormones. We have to know what causes such imbalance and how to preserve ourselves. We want to live long and we want to live healthy ……. and happy of course. I really appreciate your work and the way that you are really helping women all over. Thank you so much, Wray.

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 Straight Talks with Wray Whyte…

3 Essentials to look for when buying a Progesterone Cream: Are the ingredients safe? Is the Progesterone well absorbed? What is the amount of active ingredients in the cream?  Look for Natural Preservatives instead of synthetic one  and make sure you are not paying for the price of fancy container but rather for the amount of progesterone in the cream.

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Transcript of the interview

 Vero Laos: The question that many, many people would ask in regards to the choosing the right progesterone cream. There are so many progesterone creams on the market today.

Wray Whyte: I don’t mind what cream or what suppository or however people take it, I mean, I’ll answer any questions. It doesn’t make any difference to me. But what I do ask people to look for is the ingredients, are they safe? Because some of them have got adverse effects and is it absorbed?

We run saliva tests periodically to see if the progesterone is being absorbed. So, a naturopath does it for us, she gets a patient who’s never had it, she does it before test and then a month or two later an after test. The progesterone in every case shoots up. So, it’s absorbed very well.  So, if you use a cream, some people have said they’ve used one which is incredibly thick and takes a long, long time to rub in. That shouldn’t be the case. You shouldn’t have to rub it in a long time. So, you need to look at what carrier, the thickness, the toxic ingredients if there are any. A lot of doctors prefer using injection and suppositories. They also like the oral or the fizzy vaginal tablet because it gives you a dose, they are used to doses. To my mind, progesterone should not be done in dose form. It should be solely by symptom. So, I prefer a cream for that reason.

You don’t have a measured amount.  So, for instance, if somebody’s using suppositories and they want to reduce the amount because their symptoms have gone, what do you do? Shave a bit off the suppository each day to get less progesterone, cut it in half a quarter? The same with injections which are apparently very painful, you could give half an injection I suppose, same with the capsules. In fact, if people are taking capsules, I say, cut it open, add it to a cream and rub it on your skin instead.

The other advantage to cream, it can just be put anywhere. It is the best burn ointment I have ever come across. So, people have used it to heal leg ulcers, just filling up the ulcer with progesterone in places and other minor wounds. You can’t do that with a suppository or an injection. So, I always asked them to look at the ingredients and the amount obviously, if you’re buying something which isn’t as strong because a lot of people look at the price of the container. They don’t look at the fact that they’re actually buying an active ingredient. If they work out a comparison, they’ll find that in some cases, they’re paying twice what they would be paying with another brand. That is the important thing to look at, not the price of the container. So, those are the things I would ask people to look for.

Vero Laos:  You did mention the toxic ingredients that we have to watch out. Can you just expand a bit more on that?

Wray Whyte:  Some of the preservatives they use. The Parabens have been used for years. There have been papers done on them that say they are still safe and some that advice not using them.  The Propyl paraben has got slight estrogenic properties. So, maybe it’s advisable not to use something with that in and another one that people favour is Phenoxyethanol. Its hazard rating isn’t very high but it is a synthetic so I wouldn’t recommend using it. Antioxidants, mostly people use Rosemary or Vitamin E for the antioxidant properties it has. I haven’t yet seen in the progesterone creams, BHA or BHT. Now, those are synthetic antioxidants used in a lot of fried foods and baked foods, biscuits and cookies and things like that but those have got estrogenic properties. But as I‘ve said, I haven’t seen those used in progesterone creams but certainly in other creams. So, look for the natural antioxidants, natural preservatives rather than synthetic.

You know, you’re using a progesterone cream all you actually need is a vehicle which is an oil to get it into the skin. You do not need 20 other ingredients added to it. Just add some cost to the cream. So, that’s one reason why we’ve kept no unnecessary added ingredients. I remember once, you asked me about the liposomes’ and we never got to finish that. I think we got cut off. A lot of creams are saying that they’ve got liposomes in them but it’s a very expensive system for getting drugs into the body. You can put a tiny amount of liposomes into a cream and say its got liposome’s in it. But it won’t be based solely on just liposomes because they’re far too expensive. It will have other oils in it as well. And, from the saliva tests we run, we found they’re not necessary, not at all. Progesterone gets into the tissue. So, it’s an expensive cream which to my mind is not worth bothering with.

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Many people have a misconception that progesterone and synthetic progestins (as found in HRT and the pill) is the same hormone.

They are not!

This confusion, even among certain health care professionals, misleads into believing that natural progesterone poses a cancer threat.

Studies published in 1995 found that women who had been exposed to HRT for longer than 5 years had a 32% increased risk of getting breast cancer. If the estrogen was combined with a progestin, it went up to 41%, and for those women who were post-menopausal the risk went up to 71%, while the risk of getting ovarian cancer went up by 72%. Further sub analysis showed that the SYNTHETIC PROGESTIN was actually the culprit causing the increased breast cancer risk. (Source Dr Anna Garrett)

Clinical studies by the Emory University suggest that progesterone is a beneficial and effective hormone. The University has been investigating this hormone for the last 20 years. A study conducted in 2006 on the victims of traumatic brain surgery also established that progesterone is effective in reversing the brain oedema after the injury. Progesterone showed no harmful side effects on the victims.

There are many studies that suggest how progesterone protects from cancer by activating the gene p53. Abnormal cells keep growing and multiplying when this gene is inactive.
Too much estrogen is known to trigger heart diseases and cancer. Progesterone protects from cancer by slowing down the production of the estrogen.
Various studies highlight the protective function of progesterone in the body. It prevents hypertension, lowers blood fat, prevents coronary artery disease, protects from endometrial and ovarian cancer, and epilepsy. The presence of progesterone in the body is essential for a healthy pregnancy as well as preventing miscarriages, it also aids in vasomotor symptoms.

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Progesterone protects from Cancer

The alarmingly increased rate of cancer is a result of pollution, toxins from agriculture and industry, processed foods and increase usage of prescription medicines such as estrogen. Studies reveal that only 5% of cancer is heredity.

A study in 2002 also revealed that the increasing occurrence of cancer in humans is due to a lack of UV-B and vitamin D3. Experts suggest by having careful exposure of sun and taking vitamin D supplements regularly can help in reducing the rate of cancer. Progesterone and vitamin D are of similar nature and studies suggest that a lack of vitamin D reduces the benefits of progesterone.

Exposure to high level of estrogen can result in cancers of the breast, ovaries, and endometriosis in women and prostate, testicular, and breast cancer in men.
The studies also highlight the fact that the longer a woman is exposed to her own natural estrogens, she will be at a greater risk of developing breast cancer. Women who have low levels of progesterone are 5% more at risk of developing cancers.

How much progesterone to use?

The daily recommended progesterone dosage for women is 100 -200 mg daily, and for men it is between 10 – 100 mg per day. However the dosage should be increased until the estrogen dominance symptoms are taken care of. Progesterone can be used to sooth the radiation burn of radio-therapy and regenerate the skin. Progesterone is neuro protective agent as well as prevents lipid per-oxidation and protects the vascular system. This hormone works as an anti-inflammatory agent and is known to reduce the response of natural killer cells.
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Low progesterone is considered to be the main cause of the pre-menstrual syndrome (PMS). PMS highly affects a women’s physical and mental state. The symptoms of PMS can range from depression, anxiety, weigh gain, mood swings, raging temper, cramps, dizziness, and dehydration to different types of skin problems.

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Beware of Low Progesterone and high Estrogen

Nowadays more and more women start experiencing anovulatory cycles (no ovulation). This has caused PMS to increase for women in their 30’s. This hormonal imbalance is caused by low progesterone and high estrogen levels, due to the influence of xeno-estrogens, an endocrine disruptor which mimic the action of estrogen in the body.

Teenage girls have also started to experience low progesterone and PMS due to the high level of estrogen in their body.
Estrogen dominance suppresses the activity of the thyroid glands, which will give you a temporary hypoglycemia (low blood sugar). This triggers the adrenaline which makes women more irritable and temperamental.

I would suggest small regular meals of proteins and complex carbohydrates every three to four hour to stabilize blood sugar levels.

Weight gain is a result of low progesterone and PMS

In order to raise their blood sugar, women with PMS usually gain weight two weeks before their periods due to cravings for sweet foods. Some women can gain up to 5 kg or more which make them look like they are pregnant, which gets really distressing!!
Natural progesterone therapy will help you control your weight by balancing the estrogen level and adjusts the hormonal imbalance.

Avoid birth control pill to treat PMS

Some doctors and gynecologists prescribe pills such as birth control pills, etc. for PMS. It contains progestin and progestogens which is NOT bio-identical progesterone. This treatment should be avoided as it causes women to become more estrogen dominant, making the PMS worse. To increase the Bio-identical Progesterone dosage for PMS should be considered as the prime treatment.

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Progesterone Dosage for PMS

Usually 400mg/day of progesterone cream is needed to stop heavy bleeding and this corrects the cycle as well.

You could also consider taking at least 2000mg/day NAC (N-acetyl cysteine), 2000mg/day taurine and at least 5000iu vitamin D. Taurine is low in dysfunctional uterine bleeding, and vitamin D is a vital nutrient, a lack causes cells to malfunction, and reduces the benefits of progesterone. Initially progesterone can upset the cycle, but it should have settled by now.

Extract taken from Dr Katherina Dalton’s book ‘PMS The Essential Guide to Treatment Options

Chapter 13
It is a well-recognized fact about PMS that most sufferers are free of their monthly problems when pregnant, or at least during the second half of pregnancy. This is because the placenta produces huge amounts of progesterone to keep the pregnancy going – it may raise the level of progesterone in the blood to 40 or even 50 times the greatest amount found in non-pregnant women. However, there are a few women who continue to experience their PMS symptoms daily during later pregnancy, and these women are the ones who are most at risk of developing pre-eclampsia (page 150).

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Hot flashes are usually worse towards the end of Peri-menopause and at the beginning of menopause. During that transition period about 50% of women experience them, and many continue to do so for several years.

During this time, anovulatory cycles occur more frequently, which reduces the production progesterone in the body. While ovarian estrogen does not fall until the last viable egg has completed its development. Moreover, oestrone (estrogen) is still produced by fat (adipose) cells. It causes an imbalance as progesterone is not able to counter the excess of estrogen.
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What can cause Hot flashes?

Hot flashes increase in severity and frequency just before menopause, when menstrual cycle becomes irregular (peri-menopause).

Progesterone drops sharply during the last year or two of peri-menopause, but estrogen does not. When the ratio is disturbed, hot flashes occur.

When blood glucose drops too suddenly after eating or drinking something sweet, it causes a surge in adrenaline and noradrenaline that cause a hot flush.

A drop in serotonin caused by stress can trigger a hot flush. This drop can occur due to a lack of the precursor amino acid tryptophan in the diet, or a reduced ability to convert tryptophan into serotonin.

Men also experience hot flashes. It can be caused by low testosterone, particularly in older men going through andropause. It can also happen during anti-androgen therapy for prostate or testicular cancer, or after removal of the testes.

Hot flashes and sweating are more prevalent in menopausal women with Insulin Resistance and Metabolic Syndrome (MetS), which are risk factors for cardiovascular disease.

The benefits of Progesterone Cream for Hot flashes:

  • Progesterone is a strong anxiolytic, partly due to its action on the GABA receptor sites. GABA is a calming neurotransmitter.
  • Progesterone partially prevents the release of adrenaline and noradrenaline from the adrenals.
  • Progesterone is an anti-inflammatory hormone, mainly due to its metabolite allopregnanolone as opposed to estrogen which is an inflammatory agent.
  • Progesterone is also a potent vasodilator, it reduces blood pressure, plus it increases the production of Nitric Oxide which is a powerful vasodilator –
  • Progesterone will restore imbalance in the progesterone to estrogen ratio, and help eliminate hot flashes

    All these factors helps reduce and eliminate hot flashes!!

Natural treatment & Cure for hot flashes

In seeking a cure for hot flashes it’s essential to:

  • Reduce stress.
  • Keep blood glucose stable by avoiding all sugars or starchy food or drink containing sugar,
    (grains, legumes or sweet fruits and vegetables that fall into this category).
  • Use Bio-identical Progesterone cream to preserve the ratio of progesterone to estrogen high. 600:1 is recommended to feel well!
  • Deep breathing exercises and acupuncture can help reduce the stress linked to hot flashes

In average menopausal women require 100-200mg/day progesterone unless symptoms are severe. Once the hot flashes have started, it will only respond to levels of 400mg/day or more.
Men need 10-100mg/day progesterone, but 100mg/day and over will be needed to stop hot flashes.
Consider supplementing with:
Tryptophan/5-HTP, the precursor amino acid to serotonin,
Tyrosine, the precursor amino acid to dopamine. By raising the dopamine levels, it will inhibit prolactin production.
Vitamin D is also essential for the normal functioning of all cells. It’s also a potent anti-inflammatory and antioxidant, have a test done!

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