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Using Progesterone to Prevent Infertility and Recurrent Miscarriage

Many women are infertile due to multiple early miscarriages!
In my interview with Wray Whyte, she shows us that if early progesterone fails to rise, after ovulation, implantation doesn’t take place.

Interview transcript:

Many women could possibly be miscarrying after two weeks, but not even aware that they’re pregnant, because they bleed, but they could be bleeding an embryo that is fertilized. “ and she went on to explain how to prevent this issue by using progesterone.
Interesting to see what she said a few years ago is being backed recently, by team of researchers at the Yale School of Medicine and University of Illinois at Chicago, who stated: “Micronised plant-derived progesterone could give hope to women who suffer multiple miscarriages in the first four to five weeks of pregnancy.” (*ref:1)

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Can Infertility & Miscarriage be caused by a lack of Progesterone?
Transcript of the Interview

Vero: Let’s speak on the fertility issue because it’s something that…

Wray: Yes, that’s fine.

Vero: carries so much…emotion.

Wray: Yes.

Vero: and the woman can be so desperate and really trying anything to fall pregnant.

What are the causes of Infertility & Miscarriage?

Wray: It’s such a huge topic. And there are so many things that can cause infertility. One, of course, is nutrition, not having the right nutrients. I think, going back to vitamin D again, a lack of it can cause anovulation.  It can stop ovulation. And if you don’t ovulate, you won’t fall pregnant.  And if this happens, the women are put onto ovulation stimulation drugs, rather than trying natural things like vitamin D.

I find very intriguing because it’s something that you never hear about it, or you never read about it. Everybody is told, and everybody believes, that progesterone only rises at ovulation.  And this isn’t true.  There’s a pre-ovulatory rise up to 50 hours prior to ovulation.  And it’s coming from the brain.  And they now believe that this rise in progesterone from the brain (***ref:1) causes LH (Luteinizing Hormone) to rise, which then initiates ovulation.  And it’s not LH rising and causing ovulation, it needs the progesterone to rise, so in other words, progesterone is initiating ovulation itself.  But it’s directed from the brain because prior to this sort of discovery, they thought that progesterone was only produced by the corpus luteum, not by the brain.  Well there’s been huge research now and it is produced by the brain.

So this surge of progesterone prior to ovulation, causing LH to surge, causing ovulation…so progesterone keeps rising because after ovulation obviously it keeps rising. I think instead of giving ovulation induction drugs, which causes LH to rise, causing ovulation, try progesterone before ovulation, within that 50 hour time span.

And I would be so fascinating to find if using progesterone, just those few hours prior to ovulation would cause your LH to go up, which will then cause you to ovulate, rather than take the drugs.  They’ve never done a study on it. But it’s worth trying. And then…they’ve also found essential to egg implantation, is an early progesterone rise, after ovulation.  If it’s too low, implantation doesn’t take place.  So again, if you use progesterone within the 50 hours before ovulating, that would ensure you have that early progesterone rise after ovulation because you’re now full of progesterone.  And the egg implantation would be much more successful.

And then the other thing of course, is where the corpus luteum doesn’t make enough progesterone.  So then they’re given drugs like HCG to stimulate the corpus luteum to make more progesterone.  But it’s so interesting because another study has found that progesterone itself causes…or stimulates, its own, production.  There is no negative feedback system in that corpus luteum-progesterone, cycle.  It’s unlike any other system in the body, which always has that negative feedback. It doesn’t with progesterone, you know with the progesterone cycle.  So using progesterone prior to ovulation would give you that first initial rise which would help ovulation; it would also ensure that you have the high initial rise which is vital for implantation and then it would also continue to give you the progesterone if the corpus luteum is not making enough.  So your chances of success are greater.

And then, you’ll know two weeks later, if you you’ve conceived at ovulation, or roundabout, and, but if you’re not using enough progesterone, it doesn’t support that pregnancy.

So I think that many women could possibly be miscarrying after two weeks, but not even aware that they’re pregnant, because they bleed, but they could be bleeding an embryo that is fertilized.  And so, if you use progesterone for helping with pregnancy, it’s essential not to stop it if you are using it, [like, when you follow your cycle], because if you stop you’ll bleed.  So you would continue using the progesterone.

Continue using Progesterone if you don’t bleed!

If you’re not pregnant, you will bleed.  Even if it’s a few days later, you will, unless you’re using very, very high doses like 400mg a day. You will bleed.  And then you can stop using the cream.  But if you don’t bleed, then the chances are you are pregnant and therefore you must continue on with it.

The other thing that saddens me is that women are given progesterone, usually suppositories, if they’re, they’ve had, intrauterine insemination (IUI) or in vitro fertilization (IVF), and then they’re given it for maybe six weeks, or two months, at the most for three months and then they’re told to stop.
Now that’s going cold turkey off progesterone.  And one of the causes of miscarriages is a drop in progesterone.  So they must never go cold turkey off of it, they come off it very, very slowly.  That’s why I prefer the cream because you can do it slowly.  With suppositories, well I’ve had to tell the girls “well, cut the suppository into bits, and use the bits.” You know, how do you do slowly?  Same with injections.  You can’t slowly reduce on an injection. It’s sort of all or nothing.

Just as a recap, progesterone 50 hours before ovulation, or in that range, continue with it (progesterone), right through when you would be getting your period, i.e. two weeks later; and if you bleed, then you stop using the cream.  If you don’t, continue, then you’ll have a test and then, hopefully, you’re pregnant.

Vero: How much progesterone when we talk about infertility, what would be the recommended doses?

Wray: Well, I always stick to 100-200mg daily and always use the progesterone before falling pregnant.  So many women fall pregnant but because the doctor might be worried about miscarriages, they’ll be given progesterone at, maybe, the four week interval: they’re now four weeks pregnant. They get estrogen dominance, all the symptoms.  And they must use it before they fall pregnant.  And overcome all that, learn how to use it, what it feels like etc., before falling pregnant.



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